The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors might bring about an increase in methadone plasma concentrations, which could lead to potentially deadly respiratory despair. In addition, discontinuation of concomitantly utilised cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may also result in a ri… Read More